Early Twentieth Century
- Urania, one of the UK's first LGBT publications launches. It is run by transwoman Irene Clyde, Eva Gore-Booth and her partner Esther Rope, who was one of the first female graduates from the University of Manchester.
1967 - Homosexuality is decriminalised in the UK
- The bookshop Empire Trading Company opens on Newton Street; the first establishment to sell LGBT literature.
- Chief Constable James Anderton accuses gay men of "swirling in a cesspit of their own making" and supposedly encourages his officers to expose anyone caught in compromising situations. Motorboats with spotlights travel the canal, attempting to deter and catch gay men.
- Manchester City Council passes a number of anti-discrimination policies on the basis of sexuality, leading to many Gay Rights initiatives championed by the Council itself. These included a HIV/AIDS unit, emphasis on strengthening the community of The Village and major support for Mardi Gras.
1988 - Section 28 is introduced
- 20,000 people gather in Albert Square to protest against Section 28. Manchester City Council becomes a leading voice opposing the law implemented by Margaret Thatcher preventing the promotion of homosexuality by local authorities and schools.
- The city opens its first Lesbian & Gay Centre on Sidney Street.
- The Rembrandt hosts Manchester's "first Pride", which was a bring and buy sale for victims of HIV/AIDS.
- Manchester gay businessman Nigel Martin Smith launches the boyband Take That with appearances in gay bars across the city. Despite all members of the band's heterosexuality, they are deliberately marketed towards gay men, establishing a precedent that continues in pop music to this day.
- Paradise Factory, one of the city's most iconic gay clubs opens. Opened by Joan Collins driven on stage in a Mini, it would continue to run until the early 00s.
- Iconic Manchester soap Coronation Street introduces the first transgendered character on a UK soap: Hayley Cropper, played by Julie Hesmondhalgh. She would continue to appear in the show until 2014.
2003 - Section 28 is repealed
- Rainbow tiled mosaics are installed in the pavements across the city to mark the key spots of Manchester's LGBT History.
2006 - Same-sex civil partnerships legalised in the UK
- Manchester's 'Homo Hero' Jackie Crozier steps down as Director of Manchester Pride, after building it to become one of the biggest and most popular Prides in Europe.
2013 - Same-sex marriage is legalised in the UK
- Newspapers theorise that a serial killer named 'The Pusher' has been stalking the canals of Manchester, targeting gay men. Police debunk the claim, even though sixty bodies have been pulled from the waterways around The Village within the past six years.
- Russell T. Davies revisits Canal Street 16 years since Queer As Folk in the form of the colourful and dramatic serials Cucumber and Banana on Channel 4.